DSIP 10mg

Product Summary Table

Name	DSIP Peptide (Delta Sleep Inducing Peptide)
Total Content	10mg
Type	Neuropeptide research compound
Amino Acid Sequence	Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE)
Molecular Weight	~850.9 g/mol
Form	Freeze-dried powder (lyophilised)
Storage	Store at 2–8°C in dark conditions. After reconstitution, refrigerate at 1–4°C.
Standard	Research Purity ≥99%
Country of Origin	USA

DSIP peptide, also known as Delta Sleep Inducing Peptide, is a naturally occurring neuropeptide originally isolated from cerebral venous blood and later identified in the hypothalamus, limbic system, pituitary, human plasma, cerebrospinal fluid, and human breast milk. DSIP plays a role in sleep regulation, particularly in the induction of slow wave sleep, and has been widely studied in both animal and human research models related to sleep disorders, chronic insomnia, stress, and endocrine regulation.

In Vivo Research Benefits

• Sleep Regulation and Slow Wave Sleep: DSIP is believed to promote sleep by increasing delta EEG activity, supporting deeper, more restorative sleep patterns associated with slow wave sleep.
• Chronic Insomnia Research: Studies in chronic insomniac patients show that DSIP administration may improve sleep efficiency, shorten sleep latency, and increase overall sleep quality in comparison to placebo.
• Circadian Rhythm Modulation: DSIP concentrations exhibit diurnal variation, with lower levels in the morning and higher levels later in the day, suggesting involvement in circadian timing mechanisms.
• Stress and Emotional Regulation: Research indicates DSIP may improve stress tolerance and coping behaviour by influencing hypothalamic-pituitary-adrenal (HPA) axis activity.
• Analgesic and Antinociceptive Effects: DSIP has demonstrated potential in reducing pain perception in chronic pain models, migraines, and tension-type headaches.
• Neuroprotective Properties: Animal studies suggest DSIP may provide neuroprotection in stroke and neurodegenerative disease models.
• Endocrine and Metabolic Regulation: DSIP has been linked to modulation of body temperature, hormone secretion, and neuroendocrine balance.

Pharmacokinetics and Biological Characteristics

• DSIP is synthesised in the hypothalamus and targets multiple brainstem sites.
• It can cross the blood-brain barrier and has been shown to be absorbed from the gut in experimental settings.
• DSIP has a short half-life in human plasma of approximately 7–8 minutes.
• Found in both free and bound forms in central and peripheral tissues.
• Minimal effects observed in healthy subjects without sleep disturbance.

Dosage and Administration

• Form: Lyophilised peptide for reconstitution.
• Usage: For research use only.
• Delivery methods used in research include subcutaneous or intravenous administration due to enzymatic degradation when taken orally.
• This product is not approved for human consumption, therapeutic use, or cosmetic application and is not approved under the Federal Food, Drug, and Cosmetic Act.

Studies and Additional Info

• https://pubmed.ncbi.nlm.nih.gov/1299794/
• https://pubmed.ncbi.nlm.nih.gov/6145137/